Copying files form hard drive in NTFS to exFAT USB

edited April 2011 in NTFS File System
I have Vista Premium formated in NTFS, and a 256Gb USB drive formated in exFAT (I also tried FAT32).  When I copy files from the laptop's NTFS to the USB drive I cannot open them.  For example an MP3 file will not open with Windows Media Player.  Is there a way to convert NTFS to exFAT, or to work with the two file structures.  Or are they simply incompatible?
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